(S,R,S)-AHPC-Me-12-4-Bromobutyl)amino)dodecanamide
(S,R,S)-AHPC-Me-12-4-Bromobutyl)amino)dodecanamide incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-Me-12-4-Bromobutyl)amino)dodecanamide can be used in the synthesis of PROTACs, such as MS934 (HY-153863). MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader.
Internal Reference:
cell25sk21989